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Vancouver scientists find cancer

From left, Dr. Paul Yong and Dr. Mike Anglesio have discovered cancer related gene mutations in benign tissue of women with endometriosis, a common inflammatory condition causing pelvic pain and infertility. Women's Hospital lab. Their study is published in the New England Journal of Medicine. Photo by

Mark van ManenEndometriosis causes intense pelvic pain, menstrual abnormalities and even infertility. It is characterized by tissue that normally linesthe uterus migrating outside the organ, causing lesions throughout the pelvic cavity. The bumpy growths can migrate to areas like theovaries, colon, bladder, rectum, ureter and appendix. The condition regresses after menopause.

"Finding these mutations in non cancer conditions is largely uncharted territory," he said. Cancer Research Centre.

A low percentage of cases of endometriosis are linked to a type of ovarian cancer, butthe study showed that most of the tissue samples had mutations linked Hermes belts replica paris to cancer. Paul Yong, referring to the possibility that mutations usually associated with cancer may not always be somenacing as to cause cancer. But scientists needsto learn more, through a bigger, longer study, about what puts the brakes on the mutations, especially if there are certain "micro environments" that hinder the transformation of growths from being merely abnormal to becoming malignant. Women's Centre for Pelvic Pain and Endometriosis, hermes brown belt imitation said the lesions feed on estrogen, which is why progestin only hormone pillsare often recommended as treatment. Or, in the case of women seeking to become pregnant, minimally invasive surgery by specialists can be done to remove lesions.

For the study, researchers used gene sequencing technology to analyze endometrial tissue collected during surgery from 39women in Vancouver, hermes belt price replica New York andJapan. While there are three known types of endometriosis, researchers confined their analysis to a nasty subtype called deep infiltrating endometriosis that causes pain during periods, intercourse and bowel movements. Most of the tested samples harboured single or multiple gene mutations. "These mutations are a first step in understanding the breadth of symptoms and outcomes that affect every patient differently.

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